University of Minnesota
Department of Food Science and Nutrition
http://fscn.cfans.umn.edu
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Department of Food Science and Nutrition

Sabrina (Peterson) Trudo


Dr. Sabrina (Peterson) Trudo Ph.D., R.D., Associate Professor
Department of Food Science and Nutrition
265 FScN
Phone: (612) 625-1785
Fax: (612) 625-5272
trudo@umn.edu

 

Research

My research program investigates diet and cancer prevention. Our current focus is the
effects of plant foods and their constituents on biotransformation enzymes, carcinogen
metabolism, cancer stem cells, and related miRNA expression. Additionally, we work
in the area of developing biomarkers of dietary exposure to putative chemopreventive
phytochemicals. I am also interested in the effects of gene-diet interactions on the
activity of biotransformation enzymes. Our overall goal is to identify diet-based
strategies that decrease the risk of developing cancer.

Collaborations

• Masonic Cancer Center, University of Minnesota, Minneapolis, MN
• Gustavus Adolphus College, St. Peter, MN
• Fred Hutchinson Cancer Research Center, Seattle, WA

Resident and Outreach Teaching

NUTR 5624 Nutrition and Genetics
FSCN 3614 Nutrition Education and Counseling
Guest lectures in NUTR 8620 Advances in Nutrition, ANSC 1011 Animals and Society
Guest lectures in community organizations and companies in the nutrition industry

Selected Scholarship


Larson ED, Groskreutz SR, Harmes DC, Gibbs-Hall IC, Trudo SP, Allen RC, Rutan
SC, Stoll DR. (2013) Development of selective comprehensive two-dimensional
liquid chromatography with parallel first dimension sampling and second dimension
separation – application to the quantitative analysis of multiple furanocoumarins in
apiaceous vegetables. Anal Bioanal Chem. In press.

Gallaher CM, Gallaher DD, Peterson S. (2012) Development and validation of a
spectrophotometric method for simple quantification of total glucosinolates in
cruciferous vegetables. J Agric Food Chem. 60:1358-1362.

Kang AY, Young LR, Dingfelder CS, Peterson S. (2011) Effects of furanocoumarins
from apiaceous vegetables on the catalytic activity of recombinant human cytochrome
P-450 1A2. Protein J 30:447-456.

Kim JK, Choi SJ, Bae H, Kim CR, Cho HY, Kim YJ, Lim ST, Kim CJ, Kim HK,
Peterson S, Shin DH. (2011) Effects of methoxsalen from Poncirus trifoliata on
acetylcholinesterase and trimethyltin-induced learning and memory impairment. Biosci
Biotechnol Biochem 75:1984-1989.

Kim JK, Choi SJ, Cho HY, Kim YJ, Lim ST, Kim CJ, Kim EK, Kim HK, Peterson S,
Shin DH. (2011) Ipomoea batatas attenuates amyloid beta peptide (Aβ)-induced
neurotoxicity in ICR mice. J Med Food 14:1-6.

Kim JK, Choi SJ, Cho HY, Hwang HJ, Kim YJ, Lim ST, Kim EK, Peterson S, Shin DH.
(2010) Protective effects of kaempferol (3,4’,5,7-tetrahydroxyflavone) against amyloid
beta peptide (Aβ)-induced neurotoxicity on ICR mice. Biosci Biotechnol Biochem
74:397-401.

Peterson S, Yuan JM, Koh WP, Sun CL, Wang R, Turesky RT, Yu MC. (2010) Coffee
intake and risk of colorectal cancer among Chinese in Singapore: the Singapore
Chinese Health Study. Nutr Cancer. 62:21-9.

Turesky RJ, Yuan JM, Wang R, Peterson S, Yu MC. (2007) Tobacco smoking and
urinary levels of 2-amino-9H-pyrido[2,3-b]indole in men of Shanghai, China. Cancer
Epidemiol Biomarkers Prev 16:1554-60.

Navarro SL, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD,
Lampe JW. (2009) Modulation of human serum glutathione S-transferase-α
concentration by cruciferous vegetable supplementation in a controlled feeding study is
influenced by GSTM1 and GSTT1 genotypes. Cancer Epidemiol Biomarkers Prev
18:2974-2978.

Peterson S, Schwarz Y, Li SS, Li L, King IB, Chen C, Potter JD, Lampe JW. (2009)
CYP1A2, GSTM1, and GSTT1 polymorphisms and diet effects on CYP1A2 activity in a
crossover feeding trial. Cancer Epidemiol Biomarkers Prev 18:3118-3125.

Navarro SL, Peterson S, Chen C, Makar KW, Schwarz Y, King IB, Li SS, Li
L, Kestin M, Potter JD, Lampe JW. (2009) Cruciferous vegetable feeding
alters UGT1A1 activity: diet- and genotype-dependent changes in serum
bilirubin concentrations in a controlled feeding trial. Cancer Prev Res 2:345-52.

Peterson S, Lampe JW, Gross-Steinmeyer K, Bammler TK, Eaton DL. (2006)
Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2)
activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. Food Chem Toxicol
44:1474 - 1484.

Peterson S, Lampe JW, Bigler J, Horner NK, Potter JD. (2005) Cruciferae interact with
UGT1A1*28 polymorphism to determine serum bilirubin levels in humans. J Nutr 135:
1051-1055.

Lampe JW, Peterson S. (2002) Brassica, biotransformation and cancer risk: genetic
polymorphisms alter the preventive effects of cruciferous vegetables. J Nutr 132: 2991-
2994.

 

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