Campuses:
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Ph.D., Professor Department of Food Science and Nutrition 169 FScN Phone: (612) 624-0746 Fax: (612) 625-5272 dgallahe@umn.edu |
Our research program focuses overall on the influence of dietary components on the development of chronic diseases, with emphasis on events occurring within the gastrointestinal tract. Currently we are examining the effect of several different dietary components on an animal model of colon cancer. Specifically, we have recently found that cruciferous vegetables have a profound effect on reducing the number of precancerous lesions in carcinogen-treated rats. We have also examined the effect of different types of wheat on colon cancer risk, and demonstrated that red wheat is far more effective at reducing precancerous lesions in carcinogen-treated rats than white wheat. We are also currently studying the effects of different types of whole grains on the development of type II diabetes, using an animal model of this condition. We have also conducted several studies that demonstrate that dietary fibers that have a high viscosity within the gastrointestinal tract reduce body fat, without necessarily reducing body weight. That is, the viscous dietary fibers cause a shift in body composition. Studies are ongoing to understand the mechanism of this effect.
Departmental:
A.S. Csallany
Len Marquart
Xiaoli Chen
Sabrina Peterson
Mirko Bunzel
University:
Roger Ruan, Bioproducts & Biosystems Engineering
Chengguo Xing, Medicinal Chemistry & Pharmacognosy
Other Institutions:
Cathy Kotz, VA Medical Center, Minneapolis, MN
Jon Faubion, Kansas State University, Manhattan, KS
Beth Arndt, ConAgra Inc., Omaha, NE
Rui Hai Liu, Cornell University, Cornell, NY
Centers:
University of Minnesota Cancer Center
Arikawa, A.Y. and Gallaher, D.D. 2008. Cruciferous vegetables reduce morphological markers of colon cancer risk in dimethylhydrazine-treated rats. J. Nutr. 138:526-532.
Gallaher, D.D. 2007. Influence of dietary fiber on body weight regulation. In: Sports Nutrition: Energy Metabolism and Exercise. (Wolinsky, I. and Driskell, J.A., eds.), CRC Press, Boca Raton, FL.
Gallaher, D.D. and Arikawa, A.Y. 2007. Effect of cruciferous vegetables on colon cancer risk in carcinogen-treated rats (abstract), 2nd International Symposium on Human Health Effects of Fruits and Vegetables, Houston, TX, October 10, 2007.
Gallaher, D.D., Freiburger, L.M., and Nazarre, J-A. 2007. Decreases in adiposity by viscous indigestible polysaccharides in rats (abstract), ACS National Meeting Chicago, IL, March 25-29, 2007.
Gallaher, D.D., Gallaher, C.M., Plank, D.W. 2007. Alpha-Cyclodextrin selectively increases fecal excretion of saturated fats,(abstract), FASEB J. 21, 2007.
Gallaher, D.D. 2006. Dietary fiber. In: Present Knowledge in Nutrition, 9th ed. (Russell, R.M. and Bowman, B., eds.), International Life Sciences Institute Press, Washington, D.C.
Plate, A.Y.A. and Gallaher, D.D. 2006. Effects of indole-3-carbinol and phenethyl isothiocyanate on colon carcinogenesis induced by azoxymethane in the rat. Carcinogenesis 27, 287–292.
Hyejung Cho, H., Gallaher, D.D., and Csallany, A. Saari. 2005. Conjugated linoleic acid, cis-9, trans-11, is a substrate for pulmonary 15-lipoxygenase-1 in rat. J. Agric. Food Chem. 53:7262-7266
Plate, A.Y.A., Crankshaw, D.L. and Gallaher, D.D. 2005. Effect of anesthesia by diethyl ether or isoflurane on activity of cytochrome P450 2E1 and P450 reductases in rat liver. Anesth. Analg. 101:1063-1064.
Plate, A.Y.A. and Gallaher, D.D. 2005. The potential health benefits of corn components and products. Cereal Foods World 50 (6), 305.
Yang, Y. and Gallaher, D.D. 2005. The effect of dried plums on colon cancer risk factors in rats. Nutr. Cancer 53, 117-125.
Jacobs, D.R., Jr and Gallaher, D.D. 2004. Whole Grain Intake and Cardiovascular Disease: A Review. Curr Atheroscler Rep. 6: 415-23.
Khil, J. and Gallaher, D.D. 2004. Beef tallow increases apoptosis and decreases aberrant crypt foci formation relative to soybean oil in rat colon. Nutr. Cancer. 50:55-62.
Mai, V., Katki, H.A., Harmsen, H., Gallaher, D.D., Schatzkin, A., Baer, D.J., Clevidence, B. 2004. Effects of a controlled diet and black tea drinking on the fecal microflora composition and the fecal bile acid profile of human volunteers in a double-blinded randomized feeding study. J. Nutr. 134: 473-478.
Carr, T.P., Wood, K.J., Hassel, C.A., Bahl, R. and Gallaher, D.D. 2003. Raising intestinal contents viscosity leads to greater excretion of neutral sterols but not bile acids in hamsters and rats. Nutr Res. 23: 91-102.
Cho, H., Gallaher, D.D., and Csallany, A.S. 2003. Non-radiometric HPLC measurement of 13(S)-hydroxyoctadecadienoic acid from rat tissues. Anal. Biochem. 318:47-51.
Carr, T.P., Cornelison, R.M., Illston, B.J., Stuefer-Powell, C.L., and Gallaher, D.D. 2002. Plant sterols alter bile acid metabolism and reduce cholesterol absorption in hamsters fed a beef-based diet. Nutr. Res. 22: 745-754.
Cowles, R.L., Lee, J-Y., Gallaher, D.D., Stuefer-Powell, C.L., and Carr, T.P. 2002. Dietary stearic acid alters gallbladder bile acid composition in hamsters fed cereal-based diets. J. Nutr. 132: 3119-3122.
Gallaher, D.D., Gallaher, C.M., Mahrt, G.J., Carr, T.P., Hollingshead, C.H., Hesslink, R. Jr., and Wise, J.A. 2002. A glucomannan and chitosan fiber supplement decreases plasma cholesterol and increases cholesterol excretion in moderately obese normocholesterolemic humans. J. Am. Coll. Nutr. 21: 428-33.
Harris, G.K., Gupta, A., Nines, R.G., Kresty, L.A., Habib, S.G., Frankel, W.L., La Perle, K., Gallaher, D.D., Schwartz, S.J., and Stoner, G.D. 2001. Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2'-deoxyguanosine levels in the Fischer 344 rat. Nutr. Cancer. 40:125-133.
